Stroke Training and Awareness Resources (STARs)



Antiplatelet therapy

Introduction

Please note that this Topic Loop is under review and will be updated shortly to reflect the latest National Stroke Guidelines for Stroke (RCP 2023) 

Antiplatelet medications, either singly or in combinations, are frequently used to reduce the risk of a further stroke after an ischaemic stroke or TIA.

  • Antiplatelet agents make platelets less sticky and thus reduce clot formation
  • Commonly used antiplatelet medications include: aspirin and clopidogrel
  • The combination of aspirin and clopidogrel is not recommended for long term use after stroke because of an increased bleeding risk.
  • Antiplatelet drugs increase the risk of bleeding – they should be used with caution in patients with a history of bleeding or anaemia.
  • Other antiplatelet  medication is available e.g. dipyridamole, prasugrel, ticagrelor but are not used routinely. This may change depending on new evidence.

Page last reviewed: 22 Apr 2022