A grade B recommendation is more important than a grade C
The grade of recommendation relates to the strength of the evidence on which the recommendation is based. It does not reflect the clinical importance of the recommendation. (See Additional Information box at bottom of page for more information on this). e.g. Screening for swallowing problems is very important but not supported by high quality research.
Every patient admitted must be treated in accordance with the guidelines
Clinical judgement needs to be used to decide whether an individual patient is treated according to a specific guideline statement.
Guidelines always provide the most up-to-date information about how to treat patients
Guidelines are often reviewed only every few years and therefore may become out of date. Clinical practice needs to take account of the most recent clinical evidence.
High quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias, represent examples of level 3 evidence
They represent the highest level i.e. 1++. (See Additional Information box at bottom of page for more information on this).
High quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias
1+
Well-conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias
1-
Meta-analyses, systematic reviews, or RCTs with a high risk of bias
2++
High quality systematic reviews of case control or cohort or studies High quality case control or cohort studies with a very low risk of confounding or bias and a high probability that the relationship is causal
2+
Well-conducted case control or cohort studies with a low risk of confounding or bias and a moderate probability that the relationship is causal
2-
Case control or cohort studies with a high risk of confounding or bias and a significant risk that the relationship is not causal
3
Non-analytic studies, e.g. case reports, case series
At least one meta-analysis, systematic review, or RCT rated as 1++, and directly applicable to the target population; or
A body of evidence consisting principally of studies rated as 1+, directly applicable to the target population, and demonstrating overall consistency of results
B.
A body of evidence including studies rated as 2++, directly applicable to the target population, and demonstrating overall consistency of results; OR
Extrapolated evidence from studies rated as 1++ or 1+
A body of evidence including studies rated as 2+, directly applicable to the target population and demonstrating overall consistency of results; or
C.
Extrapolated evidence from studies rated as 2++
Evidence level 3 or 4; or
D.
Extrapolated evidence from studies rated as 2+
Good practice points
Recommended best practice based on the clinical experience of the guideline development group